Here is a list of advanced technologies licensed or developed by Holomic. For research contracts or collaboration please contact Ketaki Sood, Director of Product Marketing, , 310.443.2070.
A compact and high-throughput alternative to traditional microscope that can fit into your pocket
- O. Mudanyali, D. Tseng, C. Oh, S.O. Isikman, I. Sencan, W. Bishara, C. Oztoprak, S. Seo, B. Khademhosseini, and A. Ozcan, Lab on a Chip (2010), DOI: 10.1039/C000453G
- D. Tseng, O. Mudanyali, C. Oztoprak, S.O. Isikman, I. Sencan, O. Yaglidere and A. Ozcan, Lab on a Chip (2010), Cover Article, DOI:10.1039/C003477K
- O. Mudanyali, C. Oztoprak, D. Tseng, A. Erlinger, and A. Ozcan, Lab on a Chip (2010), DOI: 10.1039/C004829A
- T. Su, A. Erlinger, D. Tseng, and A. Ozcan, Analytical Chemistry (2010), DOI: 10.1021/AC101845Q
Pixel-Super Resolution Microscopes
Portable microscopes with deeply submicron resolution over an imaging area that is orders of magnitude larger than conventional microscopes
Moreover, together with advanced algorithms, this pixel-super resolution approach has been also utilized in the first lensfree tomographic imager and lensfree color microscopes, e.g., to analyze micro-scale targets in three dimensions and image Pap smear (Papanicolaou test), respectively. These microscopes provide a unique toolset to image and investigate deeply submicron features of microscopic samples with an exceptional throughput.
- Bishara, U. Sikora, O. Mudanyali, T. Su, O. Yaglidere, S. Luckhart, and A. Ozcan, Lab on a Chip (2011), DOI:10.1039/C0LC00684J
- S.O. Isikman, W. Bishara, S. Mavandadi, F.W. Yu, S. Feng, R. Lau and A. Ozcan, Proceedings of the National Academy of Sciences (PNAS) (2011), DOI:10.1073/PNAS.1015638108
- A. Greenbaum, W. Luo, T-W. Su, Z. Göröcs, L. Xue, S.O. Isikman, A.F. Coskun, O. Mudanyali, and A. Ozcan, Nature Methods (2012), DOI:10.1038/NMETH.2114
- T-W. Su, L. Xue and A. Ozcan, Proceedings of the National Academy of Sciences (PNAS) (2012), DOI: 10.1073/PNAS.1212506109
- A. Greenbaum, N. Akbari, A. Feizi, W. Luo, and A. Ozcan, PLoS ONE (2013), DOI:10.1371/journal.pone.0076475
Wide-Field Imaging of Single Nano-Particles and Viruses
Following a novel nano-lens self-assembly procedure, holographic microscopy can image single nano particles and viruses over an ultra large field-of-view
Electron microscopy is one of the gold standards to observe nanoscale objects as the scattering from an individual nanoparticle (e.g., virus) is quite weak at optical wavelengths. Utilizing lensfree holographic microscopy and self-assembled liquid nano-lenses, our high-throughput and on-chip approach provides a unique platform to image sub-100 nm particles across a large field-of-view of >20 mm2. In addition to single nano-particles that are as small as 60nm, we also imaged single H1N1 viruses and adenoviruses.
- O. Mudanyali, E. McLeod, W. Luo, A. Greenbaum, A.F. Coskun, Y. Hennequin, C. Allier, and A. Ozcan, Nature Photonics (2013), DOI:10.1038/NPHOTON.2012.337
- O. Mudanyali, W. Bishara, and A. Ozcan, Optics Express (2011), DOI: 10.1364/OE.19.017378
- E. McLeod, W. Luo, O. Mudanyali, A. Greenbaum, and A. Ozcan, Lab Chip (2013) , DOI: 10.1039/C3LC50222H